Search results for "Heterogeneous disorder"
showing 2 items of 2 documents
Long‐term molecular differences between resilient and susceptible mice after a single traumatic exposure
2022
Post-traumatic stress disorder (PTSD) is a heterogeneous disorder induced by trauma, resulting in severe long-term impairments of an individual's mental health. PTSD does not develop in every individual and, thus, some individuals are more resilient. However, the underlying molecular mechanisms are poorly understood. Here, we aimed to elucidate these processes.We used a single-trauma PTSD model in mice to induce long-term maladaptive behaviours and profiled the mice 4 weeks after trauma into resilient or susceptible individuals. The classification of phenotype was based on individual responses in different behavioural experiments. We analysed microbiome, circulating endocannabinoids, and lo…
Psicopatología de las compulsiones de lavado en el trastorno obsesivocompulsivo: no todos los pacientes lavan por los mismos motivos
2016
Abstract: Psychopathology of washing compulsions in obsessive-compulsive disorder: Not all patients wash for the same reasons. Obsessive-compulsive disorder (OCD) is a heterogeneous disorder in terms of the contents of obsessions and compulsions. Washing, being one of the most frequent compulsion modalities, has been associated with different variables such as: physical or mental contamination fears, fears associated with negative affect (including disgust) and the loss of control, a high level of perfectionism, or the avoidance of a sense of dirtiness or incompleteness. In this study, these variables are examined through the descriptive analysis of the psychopathological symptoms and tr…